Both the limited and diffuse types of scleroderma involve injury to blood vessels, inflammation, and varying amounts of fibrosis. It can affect the skin, blood vessels, muscles, joints, the gastrointestinal tract, kidneys, lungs, and heart. Systemic sclerosis (scleroderma) causes the body to destroy healthy tissue.
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- Your healthcare provider will tell you what to expect and if you have an increased risk of fatal complications.
- Trust your instincts and your body if something feels “off.” Even subtle changes in your symptoms can be a sign of an issue your healthcare provider should examine.
- Scleroderma also may cause problems in the blood vessels, internal organs and digestive tract.
- Likewise, in the United States, it is slightly more common in African Americans than in their white counterparts.
Symptoms of localized scleroderma will, in many cases, improve or go away on their own over time, but there is frequently permanent damage in the form of residual scar tissue. For some patients, localized scleroderma can be disfiguring and painful. Medications used include corticosteroids, methotrexate, and non-steroidal anti-inflammatory drugs (NSAIDs). Those with localized disease generally have a normal life expectancy. In those with systemic disease, life expectancy can be affected, and this varies based on subtype. Death is often due to lung, gastrointestinal, or heart complications.
Scleroderma is an autoimmune disease that causes inflammation and fibrosis (thickening) in the skin and other areas of the body. When an immune response tricks tissues into thinking they are injured, it causes inflammation, and the body makes too much collagen, leading to scleroderma. Too much collagen in your skin and other tissues causes areas of tight, hard skin. The cause is unknown, but it may be due to an abnormal immune response. Risk factors include family history, certain genetic factors, and exposure to silica.
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People with diffuse systemic sclerosis often suffer from fatigue, weight loss, joint swelling, tightening, and pain. Patients with the diffuse scleroderma subtype should seek early diagnosis, symptomatic and disease-modifying treatment, and frequent monitoring. The onset of diffuse scleroderma symptoms can be rapid and severe.
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Some patients do not fit the definitions of limited or diffuse systemic sclerosis. Sine (SEEN-ay) sclerosis is a rare condition that affects a small percent of people with systemic scleroderma. Patients with sine scleroderma do not have the typical hard, thick skin that is characteristic of systemic scleroderma, but still experience an abnormal buildup of scar tissue in their internal organs. For Raynaud’s, blood pressure medications called calcium channel blockers or PDE-5 inhibitors like sildenafil (Viagra) and tadalafil (Cialis), can improve circulation. Antacids and proton pump inhibitors (omeprazole) can help with heartburn.
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Diagnosis is based on history and physical exam findings, blood tests, autoantibodies seen in scleroderma, and imaging of heart or lungs. However, researchers think that the immune system overreacts and causes inflammation and injury to the cells that line blood vessels. This triggers connective tissue cells, especially a cell type called fibroblasts, to make too much collagen and other proteins. The fibroblasts live longer than normal, causing a buildup of collagen in the skin and other organs, leading to some of the signs and symptoms of scleroderma. Because internal organs are not affected by localized scleroderma, it is not a life-threatening illness and can be considered a less serious health threat than other forms of the disease.
While there is no cure for scleroderma, treatments can ease symptoms, slow progression and improve quality of life. Celebrity Equinox® is now making even more waves in the cruise world. Enjoy craft beer and comfort food in the new Craft Social and sip refreshing frozen cocktails on the pool deck at Slush. A unique experience at sea, feel grass beneath your feet at the relaxing Lawn Club. Cruises to Greece from Barcelona are a fantastic way to experience the best of the Mediterranean on one seamless voyage. Popular ports of https://traderoom.info/just2trade-forex-broker-overview/ call include Athens (Piraeus), Santorini, and Mykonos, where travellers can enjoy ancient history, breathtaking views, and authentic local cuisine.
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- Scleroderma can cause scarring in the lung tissues that may result in increasing shortness of breath over time.
- Systemic sclerosis is a potentially serious autoimmune disorder that causes atypical growth of connective tissues.
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It happens because of an exaggerated contraction of the small blood vessels in the fingers and toes in response to cold temperatures or emotional distress. When this happens, the digits may feel painful or numb and turn white, blue, gray or red. Raynaud’s phenomenon also can occur in people who don’t have scleroderma.
Limited Scleroderma, aka CREST (Limited Systemic Sclerosis) »
Treatment is typically based on your symptoms and the need to prevent complications. By analyzing your symptoms, identifying skin changes, and reviewing lab values, your doctor may determine scleroderma or SS is the cause. SS occurs when your body begins to overproduce collagen and it accumulates in your tissues. Collagen is the main structural protein that makes up all of your tissues. When this occurs, it’s called a mixed connective tissue disease. Scleroderma can be a very frustrating condition to live with.
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Collagen is a fibrous type of protein that makes up the body’s connective tissues, including the skin. When scleroderma affects the heart or lungs, it can cause shortness of breath, decreased exercise tolerance and dizziness. Scleroderma can cause scarring in the lung tissues that may result in increasing shortness of breath over time. There are medicines that may help slow the progression of this lung damage. Scleroderma is often categorized as limited or diffuse, which refers only to the degree of skin involvement. Both types can involve any of the other vascular or organ symptoms that are part of the disease.
It can change the appearance and texture of your skin and affect other organs. If your doctor suspects scleroderma, they may first order a blood test called an antinuclear antibody (ANA). If the result is abnormal, you will need a more specific blood test to look for scleroderma-specific autoantibodies. The doctor may also run a blood count test or blood chemistry panel and may do a skin biopsy, or lung, heart, and gastrointestinal tests.